Navigating this blog

I will post an evidence-based review on a off-label drug of interest from time to time (one a month on average, as I can manage).

The post will be organzed with an overview, the evidence [test-tube -> animal -> human (cases and trials)], and a “my take” or “future directions” section giving my personal opinion on how the drug can be optimally integrated into a cocktailed approach for cancer therapy.

Those interested in this general topic should browse under the TOPIC page and see what has been posted and what topics I plan to write about.

Those interested in specific cancer applications can use the “search” function, or look under tags or keywords or categories (e.g. breast cancer).  Each drug can be looked under categories of individual cancers:

Breast, Lung (NSCLC and SCL), colorectal, gastric, pancreas (under hepatobiliary), liver (under hepatobiliary), head and beck, melanoma, uterine, ovary, glioblastoma (glioma and other CNS tumors), other.

Or, they can be searched under individual mechanisms of action:

immune, apoptosis, angiogenesis,

Or, under cancer applications:

prevention, treatment, enhance chemo or radiotherapy, side-effect moderation, quality of life improvement

Feel free to contact me if you are interested in me looking into or reviewing or posting a topic drug …

  1. Jerrie Salter
    April 4, 2009 at 5:03 pm

    I have read Dr. matsumoto’s studies on cemitidine, and am currently giving my husband 800 mg daily with his Folfox and Avastin chemotheraphy. He has stae 4 colon cancer with liver mets, two very large. He has had 5 sessions, only 2 with avastin, and his last CT scan showed the tumors and all smaller leisons had shrunk over 50%. His CEA markers have dropped from 392 to 30. My question is, how long should he continue to take the cetimidine?

    Jerrie Salter

    • April 9, 2009 at 10:41 pm

      My preamble would be because I am constrained as a licensed professional, I regret that I cannot offer your husband any personal or professional advice when he is not my patient. However, given that cimetidine is over-the-counter and rather safe (though not entirely without side-effects), he can opt to take it as long as he wishes to, while following the instructions and warnings etc on the bottle. Best of luck !

  2. robert lamont dds
    November 9, 2009 at 11:44 pm

    bisphosphonates have side effects onj (osteonecrosis of the jaw) on occassion iv form a little higher than oral form…

  3. August 6, 2011 at 11:21 pm

    i like this blog…thank you for the knowledge Dr.Chang !

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